代表著作

Zhou X, Cao H, Jiang Y, Chen Y, Zhong H, Fu WY, Lo RMN, Wong BWY, Cheng EYL, Mok KY, Kwok TCY, Mok VCT, Ip FCF; Alzheimer's Disease Neuroimaging Initiative; Miyashita A, Hara N, Ikeuchi T, Hardy J, Chen Y, Fu AKY, Ip NY. Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease. Alzheimers Dement. 2025 Jan;21(1):e14214.

Wang J, Cao M, Han L, Shangguan P, Liu Y, Zhong Y, Chen C, Wang G, Chen X, Lin M, Lu M, Luo Z, He M, Sung HHY, Niu G, Lam JWY, Shi B, Tang BZ. Blood-Brain Barrier-Penetrative Fluorescent Anticancer Agents Triggering Paraptosis and Ferroptosis for Glioblastoma Therapy. J Am Chem Soc. 2024 Oct 23;146(42):28783-28794.

Wu W, He Y, Chen Y, Fu Y, He S, Liu K, Qu JY. In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons. Nat Commun. 2024 Oct 13;15(1):8837.

Chen W, Wu J, Yang C, Li S, Liu Z, An Y, Wang X, Cao J, Xu J, Duan Y, Yuan X, Zhang X, Zhou Y, Ip JPK, Fu AKY, Ip NY, Yao Z, Liu K. Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2404395121. 

Zhong H, Zhou X, Uhm H, Jiang Y, Cao H, Chen Y, Mak TTW, Lo RMN, Wong BWY, Cheng EYL, Mok KY, Chan ALT, Kwok TCY, Mok VCT, Ip FCF, Hardy J, Fu AKY, Ip NY. Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification. Alzheimers Dement. 2024 Apr;20(4):2469-2484.

Jiang Y, Uhm H, Ip FC, Ouyang L, Lo RMN, Cheng EYL, Cao X, Tan CMC, Law BCH, Ortiz-Romero P, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Mok KY, Hardy J, Kwok TCY, Mok VCT, Suárez-Calvet M, Zetterberg H, Fu AKY, Ip NY. A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups. Alzheimers Dement. 2024 Mar;20(3):2000-2015.

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J. Identifying predictors of glioma evolution from longitudinal sequencing. Sci Transl Med. 2023 Oct 4;15(716):eadh4181.

Lau SF, Wu W, Wong HY, Ouyang L, Qiao Y, Xu J, Lau JH, Wong C, Jiang Y, Holtzman DM, Fu AKY, Ip NY. The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology. Nat Aging. 2023 Oct;3(10):1219-1236. 

Zhou X, Chen Y, Ip FCF, Jiang Y, Cao H, Lv G, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RMN, Tong EPS; Alzheimer’s Disease Neuroimaging Initiative; Mok VCT, Kwok TCY, Guo Q, Mok KY, Shoai M, Hardy J, Chen L, Fu AKY, Ip NY. Deep learning-based polygenic risk analysis for Alzheimer's disease prediction. Commun Med (Lond). 2023 Apr 6;3(1):49.

Wang X, Yang C, Wang X, Miao J, Chen W, Zhou Y, Xu Y, An Y, Cheng A, Ye W, Chen M, Song D, Yuan X, Wang J, Qian P, Wu AR, Zhang ZY, Liu K. Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis. Neuron. 2023 Jan 18;111(2):236-255.e7.

Zhang T, Chen X, Yuan C, Pang X, Shangguan P, Liu Y, Han L, Sun J, Lam JWY, Liu Y, Wang J, Shi B, Zhong Tang B. Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease. Angew Chem Int Ed Engl. 2023 Jan 9;62(2):e202211550. 

Qin Z, She Z, Chen C, Wu W, Lau JKY, Ip NY, Qu JY. Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping. Nat Biotechnol. 2022 Nov;40(11):1663-1671. 

Dong A, Liu J, Lin K, Zeng W, So WK, Hu S, Cheung TH. Global chromatin accessibility profiling analysis reveals a chronic activation state in aged muscle stem cells. iScience. 2022 Aug 17;25(9):104954. 

Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VMN, Lau SF, Wu W, Wong DYK, Seo H, Fu WY, Lai NCH, Chen Y, Chen Y, Tong EP, Alzheimer’s Disease Neuroimaging Initiative, Mok VCT, Kwok TCY, Mok KY, Shoai M, Lehallier B, Morán Losada P, O’Brien E, Porter T, Laws SM, Hardy J, Wyss-Coray T, Masters CL, Fu AK, Ip NY. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nat Aging. 2022 Jul;2:616–634.

Duan Y, Ye T, Qu Z, Chen Y, Miranda A, Zhou X, Lok KC, Chen Y, Fu AKY, Gradinaru V, Ip NY. Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice. Nat Biomed Eng. 2022 Feb;6(2):168-180.

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, Chan ALT, Mok VCT, Kwok TCY, Mok KY, Hardy J, Zetterberg H, Fu AKY, Ip NY. Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging. Alzheimers Dement. 2022 Jan;18(1):88-102.

Wu MY, Wong AYH, Leung JK, Kam C, Wu KL, Chan YS, Liu K, Ip NY, Chen S. A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2106143118.

Li H, Nam Y, Huo R, Fu W, Jiang B, Zhou Q, Song D, Yang Y, Jiao Y, Weng J, Yan Z, Di L, Li J, Wang J, Xu H, Wang S, Zhao J, Wen Z, Wang J, Cao Y. De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation. Circ Res. 2021 Oct 15;129(9):825-839.

Wang Y, Yang Y, Chen S, Wang J. DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration. Brief Bioinform. 2021 Sep 2;22(5):bbab048.

Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, Greengard P. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 2021 Aug 2;218(8):e20202446.